Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion | Zendy

Urania Rappo | Zendy; Michael W. Dunne | Zendy; Sailaja Puttagunta | Zendy; James Baldassarre | Zendy; ShengFang Su | Zendy; Daksha DesaiKrieger | Zendy; Megumi Inoue | Zendy

Open Access

Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion

Author(s) -

Urania Rappo,

Michael W. Dunne,

Sailaja Puttagunta,

James Baldassarre,

ShengFang Su,

Daksha DesaiKrieger,

Megumi Inoue

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01024-19

Subject(s) - dalbavancin , staphylococcus aureus , antibiotics , microbiology and biotechnology , pharmacokinetics , medicine , streptococcus pneumoniae , pharmacology , vancomycin , biology , bacteria , genetics

Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC 90 s of Streptococcus pneumoniae and Staphylococcus aureus for ≥7 days.

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