Open AccessThe Antimicrobial Peptide MK58911-NH 2 Acts on Planktonic, Biofilm, and Intramacrophage Cells of Cryptococcus neoformans
Author(s) -
Júnya de Lacorte Singulani,
Lariane Teodoro Oliveira,
Marina Dorisse Ramos,
Nathália Ferreira Fregonezi,
Paulo César da Costa Gomes,
Mariana Cristina Galeane,
Mário Sérgio Palma,
Ana Marisa Fusco Almeida,
María José Soares Mendes-Giannini
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00904-21
Subject(s) - cryptococcus neoformans , microbiology and biotechnology , cryptococcosis , biofilm , biology , peptide , antimicrobial , aspergillus fumigatus , toxicity , chemistry , biochemistry , bacteria , genetics , organic chemistry
Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine, which causes unavoidable toxicity issues in the host.