Open AccessSusceptibility Trends of Zoliflodacin against Multidrug-Resistant Neisseria gonorrhoeae Clinical Isolates in Nanjing, China, 2014 to 2018
Author(s) -
Wei Le,
Xiaohong Su,
Xiangdi Lou,
Xuechun Li,
Xia Gong,
Baoxi Wang,
Caroline Attardo Genco,
John P. Mueller,
Peter A. Rice
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00863-20
Subject(s) - neisseria gonorrhoeae , spectinomycin , microbiology and biotechnology , quinolone , biology , tetracycline , ciprofloxacin , multiple drug resistance , liter , mtrr , virology , antibiotics , genotype , genetics , gene , methylenetetrahydrofolate reductase , endocrinology
Previously, we reported the potent activity of a novel spiropyrimidinetrione, zoliflodacin, against Neisseria gonorrhoeae isolates collected in 2013 from symptomatic men in Nanjing, China. Here, we investigated trends of susceptibilities to zoliflodacin in 986 isolates collected from men between 2014 and 2018. N. gonorrhoeae isolates were tested for susceptibility to zoliflodacin and seven other antibiotics.