IS Kpn40 -Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli | Zendy

Yuzhang He | Zendy; Tengfei Long | Zendy; Caiping Chen | Zendy; Bing He | Zendy; XingPing Li | Zendy; Jessica A. Schuyler | Zendy; Liang Chen | Zendy; XiaoPing Liao | Zendy; Ya-Hong Liu | Zendy; Jian Sun | Zendy

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IS Kpn40 -Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli

Author(s) -

Yuzhang He,

Tengfei Long,

Caiping Chen,

Bing He,

XingPing Li,

Jessica A. Schuyler,

Liang Chen,

XiaoPing Liao,

Ya-Hong Liu,

Jian Sun

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00851-20

Subject(s) - colistin , escherichia coli , mcr 1 , transposable element , transposition (logic) , gene , biology , microbiology and biotechnology , mobile genetic elements , genetics , plasmid , enterobacteriaceae , antibiotics , mutant , linguistics , philosophy

The mobile colistin resistance gene mcr-3 has globally disseminated since it was first reported in 2017 in Escherichia coli In vitro mobilization assays in this study demonstrate the functionality of the composite transposon structure IS Kpn40-mcr-3.11-dgkA -IS Kpn40 in wild-type and recA - E. coli strains. These transpositions generated 4-bp duplications at the target sites. This is the first report demonstrating the mobility of the mcr-3.11 gene by transposition.

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