Open AccessHIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis
Author(s) -
Chloé Loiseau,
Daniela Brites,
Miriam Reinhard,
Kathrin Zürcher,
Sònia Borrell,
Marie Ballif,
Lukas Fenner,
Helen Cox,
Liliana K. Rutaihwa,
Robert J. Wilkinson,
Marcel Yotebieng,
E Jane Carter,
Alash’le Abimiku,
Olivier Marcy,
Eduardo Gotuzzo,
Anchalee Avihingsa,
Nicola M. Zetola,
Basra Doulla,
Erik C. Böttger,
Matthias Egger,
Sébastien Gagneux
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00782-20
Subject(s) - rpob , coinfection , mycobacterium tuberculosis , tuberculosis , rifampicin , virology , context (archaeology) , biology , drug resistance , microbiology and biotechnology , medicine , human immunodeficiency virus (hiv) , antibiotics , pathology , paleontology
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.