Open AccessPiperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus
Author(s) -
Dereje A. Negatu,
Andreas Beuchel,
Abdeldjalil Madani,
Nadine Álvarez,
Chao Chen,
Wassihun Wedajo Aragaw,
Matthew Zimmerman,
Benoît Laleu,
Martin Gengenbacher,
Véronique Dartois,
Peter Imming,
Thomas Dick
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00676-21
Subject(s) - dna gyrase , mycobacterium abscessus , microbiology and biotechnology , mycobacterium , moxifloxacin , nontuberculous mycobacteria , biology , antibiotics , escherichia coli , bacteria , genetics , gene
New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens,Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active againstMycobacterium tuberculosis , we previously identified the piperidine-4-carboxamide (P4C) MMV688844 (844) as a hit againstM. abscessus .