Open AccessChromosomal and Plasmid-Borne Tigecycline Resistance Genes tet (X3) and tet (X4) in Dairy Cows on a Chinese Farm
Author(s) -
Rong Zhang,
Ning Dong,
Yu Zeng,
Zhangqi Shen,
Jiauyue Lu,
Congcong Liu,
Zhuo-an Huang,
Qiaoling Sun,
Qipeng Cheng,
Lingbing Shu,
Jiachang Cai,
Edward Wai-Chi Chan,
Dejun Liu,
Gongxiang Chen,
Yang Wang,
Sheng Chen
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00674-20
Subject(s) - plasmid , biology , tigecycline , acinetobacter baumannii , microbiology and biotechnology , gene , acinetobacter , bacteria , genetics , antibiotics , pseudomonas aeruginosa
We isolated 47 Acinetobacter strains carrying tet (X3) and 4 ST767 E. coli strains carrying tet (X4) from 296 rectal swab samples from dairy cows on a Chinese farm. tet (X3) was located on chromosomes or diverse plasmids, and tet (X4) was located on IncFIBκ/FIA(HI1)/X1 nontransferable plasmid. The coexistence of tet (X3) and carbapenemase genes, including bla OXA-58 and bla NDM-1 , was detected in 9 Acinetobacter spp. These findings suggested that the use of tetracycline and other antibiotics in food production warrants urgent attention.