In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress | Zendy

Crystal L. Jones | Zendy; Shweta Singh | Zendy; Yonas A. Alamneh | Zendy; Leila G. Casella | Zendy; Robert K. Ernst | Zendy; Emil Lesho | Zendy; Paige Waterman | Zendy; Daniel V. Zurawski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress

Author(s) -

Crystal L. Jones,

Shweta Singh,

Yonas A. Alamneh,

Leila G. Casella,

Robert K. Ernst,

Emil Lesho,

Paige Waterman,

Daniel V. Zurawski

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00598-16

Subject(s) - acinetobacter baumannii , colistin , catalase , microbiology and biotechnology , oxidative stress , biology , in vivo , hydrogen peroxide , bacteria , acinetobacter , antibiotics , pseudomonas aeruginosa , genetics , biochemistry

The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research