Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase | Zendy

S N Tan | Zendy; Devaraja G. Mudeppa | Zendy; Sreekanth Kokkonda | Zendy; John White | Zendy; Rapatbhorn Patrapuvich | Zendy; Pradipsinh K. Rathod | Zendy

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Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase

Author(s) -

S N Tan,

Devaraja G. Mudeppa,

Sreekanth Kokkonda,

John White,

Rapatbhorn Patrapuvich,

Pradipsinh K. Rathod

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00586-21

Subject(s) - apicoplast , plasmodium falciparum , genome , biology , plastid , dna gyrase , mitochondrial dna , apicomplexa , genetics , plasmodium (life cycle) , organelle , malaria , computational biology , gene , parasite hosting , chloroplast , escherichia coli , immunology , world wide web , computer science

Malaria parasites have three genomes: a nuclear genome, a mitochondrial genome, and an apicoplast genome. Since the apicoplast is a plastid organelle of prokaryotic origin and has no counterpart in the human host, it can be a source of novel targets for antimalarials.Plasmodium falciparum DNA gyrase (Pf Gyr) A and B subunits both have apicoplast-targeting signals.

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