Open AccessProperties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase
Author(s) -
S N Tan,
Devaraja G. Mudeppa,
Sreekanth Kokkonda,
John White,
Rapatbhorn Patrapuvich,
Pradipsinh K. Rathod
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00586-21
Subject(s) - apicoplast , biology , plasmodium falciparum , plastid , genome , dna gyrase , topoisomerase iv , genetics , malaria , gene , escherichia coli , chloroplast , immunology
Malaria parasites have three genomes: a nuclear genome, a mitochondrial genome, and an apicoplast genome. Since the apicoplast is a plastid organelle of prokaryotic origin and has no counterpart in the human host, it can be a source of novel targets for antimalarials.Plasmodium falciparum DNA gyrase (Pf Gyr) A and B subunits both have apicoplast-targeting signals.