Open AccessIn Vitro pH Activity of Ibrexafungerp against Fluconazole-Susceptible and -Resistant Candida Isolates from Women with Vulvovaginal Candidiasis
Author(s) -
Jack D. Sobel,
Katyna Borroto–Esoda,
Nkechi Azie,
David Angulo
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00562-21
Subject(s) - candida krusei , fluconazole , candida glabrata , candida parapsilosis , candida tropicalis , candida albicans , microbiology and biotechnology , vulvovaginal candidiasis , biology , mycosis , in vitro , antifungal , immunology , biochemistry
The vaginal environment with candidiasis has a pH of 3.8 to 4.5 and this has a negative effect on the activity of antifungals. Ibrexafungerp was evaluated against 187Candida isolates, including fluconazole-sensitive and -resistantCandida albicans ,Candida glabrata ,Candida krusei ,Candida parapsilosis , andCandida tropicalis with the media adjusted to pH 7.0 and pH 4.5.