Open AccessActivity of Cefiderocol Alone and in Combination with Levofloxacin, Minocycline, Polymyxin B, or Trimethoprim-Sulfamethoxazole against Multidrug-Resistant Stenotrophomonas maltophilia
Author(s) -
Mark Biagi,
Alesia Vialichka,
M Jurkovic,
Tzi Yi Wu,
A Shajee,
M Lee,
SR Patel,
Rodrigo E. Mendes,
Eric Wenzler
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00559-20
Subject(s) - stenotrophomonas maltophilia , microbiology and biotechnology , polymyxin , levofloxacin , trimethoprim , cephalosporin , stenotrophomonas , biology , pseudomonas aeruginosa , antibiotics , pseudomonas , bacteria , genetics
The production of an L1 metallo-β-lactamase and an L2 serine active-site β-lactamase precludes the use of β-lactams for the treatment of Stenotrophomonas maltophilia infections. Preclinical data suggest that cefiderocol is the first approved β-lactam with reliable activity against S. maltophilia , but data on strains resistant to current first-line agents are limited, and no studies have assessed cefiderocol-based combinations. The objective of this study was to evaluate and compare the in vitro activity of cefiderocol alone and in combination with levofloxacin, minocycline, polymyxin B, or trimethoprim-sulfamethoxazole (TMP-SMZ) against a collection of highly resistant clinical S. maltophilia isolates.