Copresence of tet (K) and tet (M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline | Zendy

Jesper Larsen | Zendy; Julie Clasen | Zendy; Julie Elvekjær Hansen | Zendy; Wilhelm Paulander | Zendy; Andreas Petersen | Zendy; Anders Rhod Larsen | Zendy; Dorte Frees | Zendy

Open Access

Copresence of tet (K) and tet (M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

Author(s) -

Jesper Larsen,

Julie Clasen,

Julie Elvekjær Hansen,

Wilhelm Paulander,

Andreas Petersen,

Anders Rhod Larsen,

Dorte Frees

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00426-16

Subject(s) - tetracycline , sccmec , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , biology , meticillin , antibiotics , genetics , bacteria

The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.

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