The bla NDM-1 -Carrying IncA/C 2 Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo | Zendy

Sead Hadžiabdić | Zendy; Jennie Fischer | Zendy; Maria Borowiak | Zendy; Burkhard Malorny | Zendy; Katharina Juraschek | Zendy; Annemarie Kaesbohrer | Zendy; Beatriz Guerra | Zendy; Carlus Deneke | Zendy; Bruno GonzálezZorn | Zendy; István Szabó | Zendy

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The bla _NDM-1 -Carrying IncA/C ₂ Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo

Author(s) -

Sead Hadžiabdić,

Jennie Fischer,

Maria Borowiak,

Burkhard Malorny,

Katharina Juraschek,

Annemarie Kaesbohrer,

Beatriz Guerra,

Carlus Deneke,

Bruno GonzálezZorn,

István Szabó

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00380-19

Subject(s) - plasmid , in vivo , biology , genetics , microbiology and biotechnology , chemistry , gene

In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a bla NDM-1 multiresistance IncA/C 2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this bla NDM-1 -carrying IncA/C 2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into the type and frequency of its structural alterations after an in vivo passage in a broiler chicken infection study.

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