Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins | Zendy

M Hashemi | Zendy; John Rovig | Zendy; Scott Weber | Zendy; Brian Hilton | Zendy; Mehdi M. Forouzan | Zendy; Paul B. Savage | Zendy

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Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

Author(s) -

M Hashemi,

John Rovig,

Scott Weber,

Brian Hilton,

Mehdi M. Forouzan,

Paul B. Savage

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00292-17

Subject(s) - colistin , klebsiella pneumoniae , microbiology and biotechnology , antimicrobial , bacteria , antimicrobial peptides , gram negative bacteria , biology , escherichia coli , genetics , gene

The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs.

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