Open AccessCarbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa
Author(s) -
Jessin Janice,
Nicholas Agyepong,
Alex Owusu-Ofori,
Usha Govinden,
Sabiha Y. Essack,
Ørjan Samuelsen,
Arnfinn Sundsfjord,
Torunn Pedersen
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00289-21
Subject(s) - biology , integrases , integrase , genetics , genome , gene duplication , recombinase , locus (genetics) , pseudomonas aeruginosa , insertion sequence , whole genome sequencing , phylogenetic tree , gene , mobile genetic elements , transposable element , bacteria , recombination
Two novelbla DIM-1 - orbla IMP-1 -containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR)Pseudomonas aeruginosa isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global high-risk clone.