Open AccessAnidulafungin and Micafungin Concentrations in Cerebrospinal Fluid and in Cerebral Cortex
Author(s) -
Joshua Marx,
René Welte,
Tiziana Gasperetti,
Patrizia Moser,
Ronny Beer,
Martin Ortler,
Martina Jeske,
R.G. Stern,
A Pomaroli,
Michael Joannidis,
Romuald Bellmann
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00275-20
Subject(s) - anidulafungin , micafungin , cerebrospinal fluid , cerebral cortex , medicine , chemistry , antifungal , amphotericin b , dermatology
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01 to 0.66 μg/ml) and micafungin levels (<0.01 to 0.16 μg/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 μg/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 μg/g, respectively. Thus, MIC values of several pathogenic Candida strains exceed concentrations in CSF and in brain.