A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae | Zendy

Concerta L. Holley | Zendy; Vijaya Dhulipala | Zendy; Jacqueline T. Balthazar | Zendy; Adriana Le Van | Zendy; Afrin A. Begum | Zendy; Shao-Chun Chen | Zendy; Timothy D. Read | Zendy; Mitch Matoga | Zendy; Irving Hoffman | Zendy; Daniel Golparian | Zendy; Magnus Unemo | Zendy; Ann E. Jerse | Zendy; William M. Shafer | Zendy

Open Access

A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae

Author(s) -

Concerta L. Holley,

Vijaya Dhulipala,

Jacqueline T. Balthazar,

Adriana Le Van,

Afrin A. Begum,

Shao-Chun Chen,

Timothy D. Read,

Mitch Matoga,

Irving Hoffman,

Daniel Golparian,

Magnus Unemo,

Ann E. Jerse,

William M. Shafer

Publication year - 2022

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00251-22

Subject(s) - neisseria gonorrhoeae , biology , genetics , missense mutation , microbiology and biotechnology , mutant , allele , antibiotics , mutation , gene

The continued emergence ofNeisseria gonorrhoeae isolates which are resistant to first-line antibiotics has reinvigorated interest in alternative therapies such as expanded use of gentamicin (Gen). We hypothesized that expanded use of Gen promotes emergence of gonococci with clinical resistance to this aminoglycoside.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research