Open AccessA Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae
Author(s) -
Concerta L. Holley,
Vijaya Dhulipala,
Jacqueline T. Balthazar,
Adriana Le Van,
Afrin A. Begum,
Shao-Chun Chen,
Timothy D. Read,
Mitch Matoga,
Irving Hoffman,
Daniel Golparian,
Magnus Unemo,
Ann E. Jerse,
William M. Shafer
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00251-22
Subject(s) - neisseria gonorrhoeae , biology , genetics , missense mutation , microbiology and biotechnology , mutant , allele , antibiotics , mutation , gene
The continued emergence ofNeisseria gonorrhoeae isolates which are resistant to first-line antibiotics has reinvigorated interest in alternative therapies such as expanded use of gentamicin (Gen). We hypothesized that expanded use of Gen promotes emergence of gonococci with clinical resistance to this aminoglycoside.