Antibacterial Effect of Caffeic Acid Phenethyl Ester on Cariogenic Bacteria and Streptococcus mutans Biofilms | Zendy

Yumei Niu | Zendy; Kun Wang | Zendy; Sainan Zheng | Zendy; Yufei Wang | Zendy; Qian Ren | Zendy; Haoran Li | Zendy; Longjiang Ding | Zendy; Wei Li | Zendy; Linglin Zhang | Zendy

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Antibacterial Effect of Caffeic Acid Phenethyl Ester on Cariogenic Bacteria and Streptococcus mutans Biofilms

Author(s) -

Yumei Niu,

Kun Wang,

Sainan Zheng,

Yufei Wang,

Qian Ren,

Haoran Li,

Longjiang Ding,

Wei Li,

Linglin Zhang

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00251-20

Subject(s) - propolis , streptococcus mutans , caffeic acid phenethyl ester , biofilm , microbiology and biotechnology , bacteria , antimicrobial , chemistry , polyphenol , caffeic acid , natural product , biology , biochemistry , food science , antioxidant , genetics

Dental caries is the most common disease in the human mouth.Streptococcus mutans is the primary cariogenic bacterium. Propolis is a nontoxic natural product with a strong inhibitory effect on oral cariogenic bacteria. The polyphenol-rich extract from propolis inhibitsS. mutans growth and biofilm formation, as well as the genes involved in virulence and adherence, through the inhibition of glucosyltransferases (GTF). However, because the chemical composition of propolis is highly variable and complex, the mechanism of its antimicrobial action and the active compound are controversial and not completely understood.

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