Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System | Zendy

Laura Fernández-García | Zendy; Felipe Fernández-Cuenca | Zendy; Lucía Blasco | Zendy; Rafael López-Rojas | Zendy; Antón Ambroa | Zendy; María López | Zendy; Álvaro Pascual | Zendy; Germán Bou | Zendy; María Tomás | Zendy

Open Access

Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System

Author(s) -

Laura Fernández-García,

Felipe Fernández-Cuenca,

Lucía Blasco,

Rafael López-Rojas,

Antón Ambroa,

María López,

Álvaro Pascual,

Germán Bou,

María Tomás

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00250-18

Subject(s) - acinetobacter baumannii , antitoxin , microbiology and biotechnology , biology , imipenem , plasmid , persistence (discontinuity) , antibiotics , toxin , bacteria , antibiotic resistance , genetics , gene , geotechnical engineering , pseudomonas aeruginosa , engineering

The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.

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