Open AccessCharacterization of bla CTX-M-27 /F1:A2:B20 Plasmids Harbored by Escherichia coli Sequence Type 131 Sublineage C1/ H 30R Isolates Spreading among Elderly Japanese in Nonacute-Care Settings
Author(s) -
Nao Matsuo,
Rionogaki,
Michiko Hayashi,
Jun Ichi Wachino,
Masahiro Suzuki,
Yoshichika Arakawa,
Kazuo Kawamura
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00202-20
Subject(s) - plasmid , multilocus sequence typing , biology , escherichia coli , typing , sequence analysis , microbiology and biotechnology , genetics , insertion sequence , sequence (biology) , gene , virology , genotype , genome , transposable element
We characterized 29 bla CTX-M-27 -harboring plasmids of Escherichia coli sequence type 131 (ST131) sublineage C1/ H 30R isolates from healthy individuals and long-term-care facility (LTCF) residents. Most (27/29) plasmids were of the FIA, FIB, and FII multireplicon type with the same plasmid multilocus sequence typing (pMLST). Several plasmids (7/23) from LTCF residents harbored only bla CTX-M-27 as the resistance gene; however, their fundamental structures were very similar to those of previously isolated bla CTX-M-27 /F1:A2:B20 plasmids, suggesting their prevalence as a newly arising public health concern.