Open AccessPyrogallol and Fluconazole Interact Synergistically In Vitro against Candida glabrata through an Efflux-Associated Mechanism
Author(s) -
Dongting Yao,
Guanyi Zhang,
Weiqin Chen,
Jia Chen,
Zhen Li,
Xin Zheng,
Hang Yin,
Xiaobo Hu
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00100-21
Subject(s) - efflux , fluconazole , candida glabrata , candida albicans , rhodamine 123 , chemistry , microbiology and biotechnology , itraconazole , pyrogallol , in vitro , pharmacology , biology , biochemistry , multiple drug resistance , drug resistance , antifungal
Candida glabrata is currently the first or second most commonly encountered non-albicans Candida species worldwide. The potential severity ofCandida resistance mandates the discovery of novel antifungal agents, including those that can be used in combination therapies.