Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms | Zendy

Arash Ghodousi | Zendy; Elisa Tagliani | Zendy; Eranga Karunaratne | Zendy; Stefan Niemann | Zendy; Jennifer Perera | Zendy; Claudio U. Köser | Zendy; Daniela María Cirillo | Zendy

Open Access

Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms

Author(s) -

Arash Ghodousi,

Elisa Tagliani,

Eranga Karunaratne,

Stefan Niemann,

Jennifer Perera,

Claudio U. Köser,

Daniela María Cirillo

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00092-19

Subject(s) - mycobacterium tuberculosis , isoniazid , tuberculosis , phenotype , microbiology and biotechnology , biology , mycobacterium tuberculosis complex , whole genome sequencing , mycobacterium , drug resistance , strain (injury) , antibiotic resistance , genetics , virology , bacteria , genome , antibiotics , medicine , gene , pathology , anatomy

MIC testing using the Bactec mycobacteria growth indicator tube system 960 of 70 phylogenetically diverse, isoniazid-resistant clinical strains of Mycobacterium tuberculosis revealed a complex pattern of overlapping MIC distributions. Whole-genome sequencing explained most of the levels of resistance observed. The MIC distribution of strains with only inhA promoter mutations was split by the current concentration endorsed by the Clinical and Laboratory Standards Institute to detect low-level resistance to isoniazid and is, consequently, likely not optimally set.

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