Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020 | Zendy

Neha Prasad | Zendy; Ian B. Seiple | Zendy; Ryan T. Cirz | Zendy; Oren S. Rosenberg | Zendy

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Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020

Author(s) -

Neha Prasad,

Ian B. Seiple,

Ryan T. Cirz,

Oren S. Rosenberg

Publication year - 2022

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00054-22

Subject(s) - antibiotics , gram , pipeline (software) , gram negative bacteria , medicine , microbiology and biotechnology , intensive care medicine , computer science , biology , bacteria , genetics , escherichia coli , gene , programming language

The World Health Organization (WHO) has warned that our current arsenal of antibiotics is not innovative enough to face impending infectious diseases, especially those caused by multidrug-resistant Gram-negative pathogens. Although the current preclinical pipeline is well stocked with novel candidates, the last U.S.

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