Open AccessTAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model
Author(s) -
Qiang Shao,
Che-Wei Chang,
Zhiyong Li,
Xinxing Yu,
Kaitlyn Ho,
Michelle Zhang,
Xin Wang,
Jeffrey A. Simms,
Iris Lo,
Jessica Speckart,
Julia Holtzman,
Gui-Qiu Yu,
Erik D. Roberson,
Lennart Mucke
Publication year - 2022
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abm5527
Subject(s) - dravet syndrome , epilepsy , neuroscience , excitatory postsynaptic potential , autism , pi3k/akt/mtor pathway , gene knockdown , hippocampus , biology , medicine , inhibitory postsynaptic potential , psychology , signal transduction , psychiatry , genetics , apoptosis
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