Open AccessBispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
Author(s) -
Hyeseon Cho,
Kristina Kay Gonzales-Wartz,
Deli Huang,
Meng Yuan,
Mary Peterson,
Janie Liang,
Nathan Beutler,
Jonathan L. Torres,
Cong Yu,
Elena Postnikova,
Sandhya Bangaru,
Chloe Adrienna Talana,
Wei Shi,
Eun Sung Yang,
Yi Zhang,
Kwanyee Leung,
Lingshu Wang,
Linghang Peng,
Jeff Skinner,
Shanping Li,
Nicholas C. Wu,
Hejun Liu,
Cherrelle Dacon,
Thomas P. Moyer,
Melanie Cohen,
Ming Zhao,
Frances Eun-Hyung Lee,
Rona Singer Weinberg,
Iyadh Douagi,
Robin Gross,
Connie S. Schmaljohn,
Amarendra Pegu,
John R. Mascola,
Michael R. Holbrook,
David Nemazee,
Thomas F. Rogers,
Andrew B. Ward,
Ian A. Wilson,
Peter D. Crompton,
Joshua Tan
Publication year - 2021
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abj5413
Subject(s) - antibody , monoclonal antibody , virology , biology , coronavirus , microbiology and biotechnology , immunology , medicine , covid-19 , disease , pathology , infectious disease (medical specialty)
Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus.