Open AccessIntranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models
Author(s) -
Neeltje van Doremalen,
Jyothi N. Purushotham,
Jonathan E. Schulz,
Myndi G. Holbrook,
Trenton Bushmaker,
Aaron Carmody,
Julia R. Port,
Claude Kwe Yinda,
Atsushi Okumura,
Greg Saturday,
Fatima Amanat,
Florian Krammer,
Patrick W. Hanley,
Brian J. Smith,
Jamie Lovaglio,
Sarah L. Anzick,
Kent Barbian,
Craig Martens,
Sarah C. Gilbert,
Teresa Lambe,
Vincent J. Munster
Publication year - 2021
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abh0755
Subject(s) - nasal administration , virology , vaccination , viral load , medicine , virus , infectious dose , viral shedding , respiratory tract , immunology , bronchoalveolar lavage , viral pneumonia , pneumonia , respiratory system , lung , covid-19 , pathology , infectious disease (medical specialty) , disease
Intranasal vaccination of hamsters and rhesus macaques with ChAdOx1 nCoV-19 reduces shedding of SARS-CoV-2 after challenge.
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