Open AccessCell type–specific microRNA therapies for myocardial infarction
Author(s) -
Bohao Liu,
Bryan Z. Wang,
Xiaokan Zhang,
Roberta Lock,
Trevor R. Nash,
Gordana Vunjak-Novakovic
Publication year - 2021
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abd0914
Subject(s) - microrna , medicine , myocardial infarction , bioinformatics , cell type , computational biology , cell , biology , gene , genetics
Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.