Open AccessEndosomal recycling reconciles the Alzheimer’s disease paradox
Author(s) -
Scott A. Small,
Gregory A. Petsko
Publication year - 2020
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abb1717
Subject(s) - endosome , disease , alzheimer's disease , medicine , neuroscience , biology , microbiology and biotechnology , pathology , intracellular
A hub-and-spoke model with endosomal recycling as the hub can reconcile the pathogenic contribution of amyloid precursor protein to Alzheimer's disease.