An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
Author(s) -
Marta de los Reyes Jiménez,
Antonie Lechner,
Francesca Alessandrini,
Sina Bohnacker,
Sonja Schindela,
Aurélien Trompette,
Pascal Haimerl,
Dominique Thomas,
Fiona Henkel,
André Mourão,
Arie Geerlof,
Clarissa Prazeres da Costa,
Adam Chaker,
Bernhard Brüne,
Rolf M. Nüsing,
PerJohan Jakobsson,
Wolfgang Andreas Nockher,
Matthias J. Feige,
Martin Haslbeck,
Caspar Ohnmacht,
Benjamin J. Marsland,
David Voehringer,
Nicola L. Harris,
Carsten B. SchmidtWeber,
Julia Esservon Bieren
Publication year - 2020
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aay0605
Subject(s) - inflammation , eicosanoid , mediator , larva , immunology , biology , microbiology and biotechnology , enzyme , ecology , biochemistry , arachidonic acid
A helminth larval extract and its componentHpb glutamate dehydrogenase induce an anti-inflammatory mediator switch to suppress type-2 inflammation.
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