Open AccessA dual apolipoprotein C-II mimetic–apolipoprotein C-III antagonist peptide lowers plasma triglycerides
Author(s) -
Anna Wolska,
Larry Lo,
Denis Sviridov,
Mohsen Pourmousa,
Milton Pryor,
Soumitra S. Ghosh,
Rahul Kakkar,
Michael Davidson,
Sierra R. Wilson,
Richard W. Pastor,
Ira J. Goldberg,
Debapriya Basu,
Steven K. Drake,
Antony Cougnoux,
Ming Jing Wu,
Saskia B. Neher,
Lita A. Freeman,
Jingrong Tang,
Marcelo Amar,
Matt Devalaraja,
Alan T. Remaley
Publication year - 2020
Publication title -
science translational medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aaw7905
Subject(s) - apolipoprotein b , apolipoprotein c2 , hypertriglyceridemia , lipoprotein lipase , medicine , chemistry , endocrinology , lipoprotein , peptide , antagonist , triglyceride , very low density lipoprotein , biochemistry , cholesterol , enzyme , receptor
An apolipoprotein C-II peptide mimetic for the treatment of hypertriglyceridemia activates lipoprotein lipase and blocks apolipoprotein C-III.
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