Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease | Zendy

Michael Ewers | Zendy; Nicolai Franzmeier | Zendy; Marc SuárezCalvet | Zendy; Estrella MorenasRodríguez | Zendy; Miguel Ángel Araque Caballero | Zendy; Gernot Kleinberger | Zendy; Laura Piccio | Zendy; Carlos Cruchaga | Zendy; Yuetiva Deming | Zendy; Martin Dichgans | Zendy; John Q. Trojanowski | Zendy; Leslie M. Shaw | Zendy; Michael W. Weiner | Zendy; Christian Haass | Zendy

Open Access

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Author(s) -

Michael Ewers,

Nicolai Franzmeier,

Marc SuárezCalvet,

Estrella MorenasRodríguez,

Miguel Ángel Araque Caballero,

Gernot Kleinberger,

Laura Piccio,

Carlos Cruchaga,

Yuetiva Deming,

Martin Dichgans,

John Q. Trojanowski,

Leslie M. Shaw,

Michael W. Weiner,

Christian Haass

Publication year - 2019

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aav6221

Subject(s) - cognitive decline , cerebrospinal fluid , trem2 , disease , medicine , alzheimer's disease , cognition , dementia , neuroscience , psychology , psychiatry , microglia , inflammation

Higher CSF sTREM2 concentrations are associated with slower rates of cognitive decline in subjects with Alzheimer’s disease.

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