Open AccessSustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
Author(s) -
Rita G. Kansal,
Noah Richardson,
Indira Neeli,
Saleem Khawaja,
Damian Chamberlain,
Marium Ghani,
Qurat-ul-ain Ghani,
Louisa Balázs,
Šárka Beranová-Giorgianni,
Francesco Giorgianni,
James N. Kochenderfer,
Tony N. Marion,
Lorraine M. Albritton,
Marko Radic
Publication year - 2019
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aav1648
Subject(s) - cd19 , systemic lupus erythematosus , b cell , medicine , cancer research , immunology , antigen , disease , antibody
CD19-targeted CAR T cells show sustained CD19+ B cell depletion and profound therapeutic benefit in ameliorating disease in mouse models of lupus.
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