In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model | Zendy

Rebecca Mandt | Zendy; María José Lafuente-Monasterio | Zendy; Tomoyo SakataKato | Zendy; Madeline R. Luth | Zendy; Delfina C. Segura | Zendy; Alba PablosTanarro | Zendy; Sara Viera | Zendy; Noemí Magán | Zendy; Sabine Ottilie | Zendy; Elizabeth A. Winzeler | Zendy; Amanda K. Lukens | Zendy; FranciscoJavier Gamo | Zendy; Dyann F. Wirth | Zendy

Open Access

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

Author(s) -

Rebecca Mandt,

María José Lafuente-Monasterio,

Tomoyo SakataKato,

Madeline R. Luth,

Delfina C. Segura,

Alba PablosTanarro,

Sara Viera,

Noemí Magán,

Sabine Ottilie,

Elizabeth A. Winzeler,

Amanda K. Lukens,

FranciscoJavier Gamo,

Dyann F. Wirth

Publication year - 2019

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aav1636

Subject(s) - dihydroorotate dehydrogenase , plasmodium falciparum , biology , in vivo , drug resistance , malaria , in vitro , virology , parasite hosting , microbiology and biotechnology , genetics , immunology , enzyme , biochemistry , world wide web , computer science

The malaria parasitePlasmodium falciparum readily develops resistance to dihydroorotate dehydrogenase inhibitors in vitro and in a mouse model of infection.

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