Open AccessThe PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
Author(s) -
Fabiana Csukasi,
Iván Durán,
Maya Barad,
Tomáš Bárta,
Iva Gudernová,
Lukáš Trantı́rek,
Jorge Martı́n,
Caroline Y. Kuo,
Jeremy D. Woods,
Hane Lee,
Daniel H. Cohn,
Pavel Krejčı́,
Deborah Krakow
Publication year - 2018
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aat9356
Subject(s) - pi3k/akt/mtor pathway , signal transduction , microbiology and biotechnology , chemistry , endocrinology , medicine , cancer research , biology
Disrupting the PTH/PTHrP-SIK3 pathway impairs degradation of DEPTOR, affects mTOR signaling, and leads to abnormalities in skeletal development.
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