Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis | Zendy

David Lagares | Zendy; Alba Santos | Zendy; Paula Grasberger | Zendy; Fei Liu | Zendy; Clemens K. Probst | Zendy; Rod A. Rahimi | Zendy; Norihiko Sakai | Zendy; Tobias Kuehl | Zendy; Jeremy Ryan | Zendy; Patrick Bhola | Zendy; Joan Montero | Zendy; Mohit Kapoor | Zendy; Murray Baron | Zendy; Xaralabos Varelas | Zendy; Daniel J. Tschumperlin | Zendy; Anthony Letai | Zendy; Andrew M. Tager | Zendy

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Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Author(s) -

David Lagares,

Alba Santos,

Paula Grasberger,

Fei Liu,

Clemens K. Probst,

Rod A. Rahimi,

Norihiko Sakai,

Tobias Kuehl,

Jeremy Ryan,

Patrick Bhola,

Joan Montero,

Mohit Kapoor,

Murray Baron,

Xaralabos Varelas,

Daniel J. Tschumperlin,

Anthony Letai,

Andrew M. Tager

Publication year - 2017

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aal3765

Subject(s) - myofibroblast , fibrosis , apoptosis , fibroblast , cancer research , microbiology and biotechnology , medicine , immunology , biology , pathology , cell culture , genetics , biochemistry

ABT-263 blocks BCL-XL to induce apoptosis in human dermal fibroblasts from patients with scleroderma and in myofibroblasts in mice, reversing dermal fibrosis.

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