Open AccessCARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases
Author(s) -
Jun Ma,
Clare L. Abram,
Yongmei Hu,
Clifford A. Lowell
Publication year - 2019
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aao3829
Subject(s) - lyn , immunology , signal transducing adaptor protein , cytokine , dendritic cell , autoimmune disease , medicine , kinase , biology , microbiology and biotechnology , signal transduction , immune system , proto oncogene tyrosine protein kinase src , antibody
Without the kinase Lyn, the adaptor protein CARD9 amplifies cytokine production in autoimmune disease.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom