Open AccessThe p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth
Author(s) -
Jianjun Zhang,
Jianping Guo,
Xing Qin,
Bin Wang,
Linli Zhang,
Yingnan Wang,
Wenjian Gan,
Pier Paolo Pandolfi,
Wantao Chen,
Wenyi Wei
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aao1052
Subject(s) - gene isoform , p70 s6 kinase 1 , microbiology and biotechnology , biology , cancer research , cell growth , kinase , phosphorylation , biochemistry , protein kinase b , gene
Breast cancer cells may release the p85 isoform of S6K1 to act in surrounding cells and promote tumor growth.
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