Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19 | Zendy

Laura A. Vella | Zendy; Josephine R. Giles | Zendy; Amy E. Baxter | Zendy; Derek A. Oldridge | Zendy; Caroline Diorio | Zendy; Leticia Kuri-Cervantes | Zendy; Cécile Alanio | Zendy; M. Betina Pampena | Zendy; Jennifer E. Wu | Zendy; Zeyu Chen | Zendy; Yinghui Huang | Zendy; Elizabeth M. Anderson | Zendy; Sigrid Gouma | Zendy; Kevin O. McNerney | Zendy; Julie Chase | Zendy; Chakkapong Burudpakdee | Zendy; Jessica H. Lee | Zendy; Sokratis A. Apostolidis | Zendy; Alexander C. Huang | Zendy; Divij Mathew | Zendy; Oliva Kuthuru | Zendy; Eileen C. Goodwin | Zendy; Madison E. Weirick | Zendy; Marcus J. Bolton | Zendy; Claudia P. Arevalo | Zendy; André Ramos | Zendy; Cristina Jasen | Zendy; Peyton Conrey | Zendy; Samir Sayed | Zendy; H.M. Giannini | Zendy; Kurt D’Andrea | Zendy; Nuala J. Meyer | Zendy; Edward M. Behrens | Zendy; Hamid Bassiri | Zendy; Scott E. Hensley | Zendy; Sarah E. Henrickson | Zendy; David T. Teachey | Zendy; Michael R. Betts | Zendy; E. John Wherry | Zendy; Sharon Adamski | Zendy; Zahidul Alam | Zendy; Mary M. Addison | Zendy; Katelyn T. Byrne | Zendy; Aditi Chandra | Zendy; Hélène C. Descamps | Zendy; Nicholas Han | Zendy; Yaroslav Kaminskiy | Zendy; Shane Kammerman | Zendy; Justin Kim | Zendy; Allison R. Greenplate | Zendy; Jacob T. Hamilton | Zendy; Nune Markosyan | Zendy; Julia Han Noll | Zendy; Dalia K. Omran | Zendy; Ajinkya Pattekar | Zendy; Eric Perkey | Zendy; Elizabeth M. Prager | Zendy; Dana Pueschl | Zendy; Austin K. Rennels | Zendy; Jennifer Shah | Zendy; Jake S. Shilan | Zendy; Nils Wellhausen | Zendy; Ashley Vanderbeck | Zendy

Open Access

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

Author(s) -

Laura A. Vella,

Josephine R. Giles,

Amy E. Baxter,

Derek A. Oldridge,

Caroline Diorio,

Leticia Kuri-Cervantes,

Cécile Alanio,

M. Betina Pampena,

Jennifer E. Wu,

Zeyu Chen,

Yinghui Huang,

Elizabeth M. Anderson,

Sigrid Gouma,

Kevin O. McNerney,

Julie Chase,

Chakkapong Burudpakdee,

Jessica H. Lee,

Sokratis A. Apostolidis,

Alexander C. Huang,

Divij Mathew,

Oliva Kuthuru,

Eileen C. Goodwin,

Madison E. Weirick,

Marcus J. Bolton,

Claudia P. Arevalo,

André Ramos,

Cristina Jasen,

Peyton Conrey,

Samir Sayed,

H.M. Giannini,

Kurt D’Andrea,

Nuala J. Meyer,

Edward M. Behrens,

Hamid Bassiri,

Scott E. Hensley,

Sarah E. Henrickson,

David T. Teachey,

Michael R. Betts,

E. John Wherry,

Sharon Adamski,

Zahidul Alam,

Mary M. Addison,

Katelyn T. Byrne,

Aditi Chandra,

Hélène C. Descamps,

Nicholas Han,

Yaroslav Kaminskiy,

Shane Kammerman,

Justin Kim,

Allison R. Greenplate,

Jacob T. Hamilton,

Nune Markosyan,

Julia Han Noll,

Dalia K. Omran,

Ajinkya Pattekar,

Eric Perkey,

Elizabeth M. Prager,

Dana Pueschl,

Austin K. Rennels,

Jennifer Shah,

Jake S. Shilan,

Nils Wellhausen,

Ashley Vanderbeck

Publication year - 2021

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.abf7570

Subject(s) - immune system , medicine , immunology , cd8 , ards , immunocompetence , disease , t cell , lung

MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1+ CD8+ T cells.

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