T cell factor 1: A master regulator of the T cell response in disease | Zendy

Giulia Escobar | Zendy; Davide Mangani | Zendy; Ana C. Anderson | Zendy

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T cell factor 1: A master regulator of the T cell response in disease

Author(s) -

Giulia Escobar,

Davide Mangani,

Ana C. Anderson

Publication year - 2020

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.abb9726

Subject(s) - master regulator , autoimmunity , regulator , biology , t cell , immune system , cell , context (archaeology) , disease , microbiology and biotechnology , immunology , transcription factor , neuroscience , medicine , genetics , gene , paleontology , pathology

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.

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