Open AccessT cell factor 1: A master regulator of the T cell response in disease
Author(s) -
Giulia Escobar,
Davide Mangani,
Ana C. Anderson
Publication year - 2020
Publication title -
science immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.83
H-Index - 51
ISSN - 2470-9468
DOI - 10.1126/sciimmunol.abb9726
Subject(s) - regulator , autoimmunity , master regulator , context (archaeology) , cell , disease , biology , t cell , immunology , function (biology) , transcription factor , cancer research , microbiology and biotechnology , immune system , medicine , genetics , gene , paleontology
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.