Assisted reproductive technologies at the nexus of fertility treatment and disease prevention | Zendy

Mary Herbert | Zendy; Meenakshi Choudhary | Zendy; Deirdre Zander-Fox | Zendy

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Assisted reproductive technologies at the nexus of fertility treatment and disease prevention

Author(s) -

Mary Herbert,

Meenakshi Choudhary,

Deirdre Zander-Fox

Publication year - 2023

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.adh0073

Subject(s) - infertility , in vitro fertilisation , assisted reproductive technology , fertility , biology , scope (computer science) , reproductive technology , nexus (standard) , disease , genetic testing , human reproduction , embryo , bioinformatics , microbiology and biotechnology , medicine , genetics , environmental health , pregnancy , computer science , cryopreservation , population , embedded system , programming language

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen embryos for inherited genetic disorders of the nuclear and mitochondrial genomes. Progress in identifying causative genetic variants has massively increased the scope of preimplantation genetic testing in preventing genetic disorders. However, because ART procedures are not without risk of adverse maternal and child outcomes, careful consideration of the balance of risks and benefits is warranted. Further research on early human development will help to minimize risks while maximizing the benefits of ART.

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