Refactored genetic codes enable bidirectional genetic isolation | Zendy

Jérôme F. Zürcher | Zendy; Wesley E. Robertson | Zendy; Tomás Kappes | Zendy; Gianluca Petris | Zendy; Thomas Elliott | Zendy; George P. C. Salmond | Zendy; Jason W. Chin | Zendy

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Refactored genetic codes enable bidirectional genetic isolation

Author(s) -

Jérôme F. Zürcher,

Wesley E. Robertson,

Tomás Kappes,

Gianluca Petris,

Thomas Elliott,

George P. C. Salmond,

Jason W. Chin

Publication year - 2022

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.add8943

Subject(s) - genetic code , isolation (microbiology) , biology , genetics , computational biology , gene , code (set theory) , amino acid , computer science , programming language , bioinformatics , set (abstract data type)

The near-universal genetic code defines the correspondence between codons in genes and amino acids in proteins. We refactored the structure of the genetic code in Escherichia coli and created orthogonal genetic codes that restrict the escape of synthetic genetic information into natural life. We developed orthogonal and mutually orthogonal horizontal gene transfer systems, which permit the transfer of genetic information between organisms that use the same genetic code but restrict the transfer of genetic information between organisms that use different genetic codes. Moreover, we showed that locking refactored codes into synthetic organisms completely blocks invasion by mobile genetic elements, including viruses, which carry their own translation factors and successfully invade organisms with canonical and compressed genetic codes.

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