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Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
Author(s) -
Wei Shao,
Tiffany W. Todd,
Yanwei Wu,
Caroline Y. Jones,
Jimei Tong,
Karen JansenWest,
Lillian M. Daughrity,
Jinyoung Park,
Yuka Koike,
Aishe Kurti,
Mei Yue,
Monica CastanedesCasey,
Giulia del Rosso,
Judith A. Dunmore,
Desiree Zanetti Alepuz,
Björn Oskarsson,
Dennis W. Dickson,
Casey Cook,
Mercedes Prudencio,
Tania F. Gendron,
John Denis Fryer,
YongJie Zhang,
Leonard Petrucelli
Publication year - 2022
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abq7860
Subject(s) - c9orf72 , neurodegeneration , tank binding kinase 1 , endosome , frontotemporal dementia , frontotemporal lobar degeneration , amyotrophic lateral sclerosis , phenotype , gene , biology , mutation , microbiology and biotechnology , protein aggregation , phosphorylation , genetics , protein kinase a , medicine , trinucleotide repeat expansion , pathology , dementia , map kinase kinase kinase , allele , disease , intracellular

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