A specific circuit in the midbrain detects stress and induces restorative sleep | Zendy

Xiao Yu | Zendy; Guangchao Zhao | Zendy; Dan Wang | Zendy; Sa Wang | Zendy; Rui Li | Zendy; Ao Li | Zendy; Huan Wang | Zendy; Mathieu Nollet | Zendy; You Young Chun | Zendy; Tian-Yuan Zhao | Zendy; Raquel Yustos | Zendy; Huiming Li | Zendy; Jianshuai Zhao | Zendy; Jiannan Li | Zendy; Min Cai | Zendy; Alexei L. Vyssotski | Zendy; Yulong Li | Zendy; Hailong Dong | Zendy; Nicholas P. Franks | Zendy; William Wisden | Zendy

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A specific circuit in the midbrain detects stress and induces restorative sleep

Author(s) -

Xiao Yu,

Guangchao Zhao,

Dan Wang,

Sa Wang,

Rui Li,

Ao Li,

Huan Wang,

Mathieu Nollet,

You Young Chun,

Tian-Yuan Zhao,

Raquel Yustos,

Huiming Li,

Jianshuai Zhao,

Jiannan Li,

Min Cai,

Alexei L. Vyssotski,

Yulong Li,

Hailong Dong,

Nicholas P. Franks,

William Wisden

Publication year - 2022

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abn0853

Subject(s) - ventral tegmental area , sleep (system call) , midbrain , neuroscience , sleep deprivation , stress (linguistics) , psychology , sleep restriction , neuropeptide , dopamine , circadian rhythm , medicine , dopaminergic , computer science , central nervous system , operating system , linguistics , philosophy , receptor

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area γ-aminobutyric acid (GABA)-somatostatin (VTA Vgat-Sst ) cells that sense stress and drive non-rapid eye movement (NREM) and REM sleep through the lateral hypothalamus and also inhibit corticotropin-releasing factor (CRF) release in the paraventricular hypothalamus. Transient stress enhances the activity of VTA Vgat-Sst cells for several hours, allowing them to exert their sleep effects persistently. Lesioning of VTA Vgat-Sst cells abolished SDS-induced sleep; without it, anxiety and corticosterone concentrations remained increased after stress. Thus, a specific circuit allows animals to restore mental and body functions by sleeping, potentially providing a refined route for treating anxiety disorders.

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