Cryo-EM structures of amyloid-β 42 filaments from human brains | Zendy

Yang Yang | Zendy; Diana Arseni | Zendy; Wenjuan Zhang | Zendy; Melissa Huang | Zendy; Sofia Lövestam | Zendy; Manuel Schweighauser | Zendy; Abhay Kotecha | Zendy; Alexey G. Murzin | Zendy; SewYeu PeakChew | Zendy; Jennifer A. Macdonald | Zendy; Isabelle Lavenir | Zendy; Holly J. Garringer | Zendy; Ellen Gelpí | Zendy; Kathy L. Newell | Zendy; Gábor G. Kovács | Zendy; Rubén Vidal | Zendy; Bernardino Ghetti | Zendy; Benjamin Falcon | Zendy; Sjors H. W. Scheres | Zendy; Michel Goedert | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cryo-EM structures of amyloid-β 42 filaments from human brains

Author(s) -

Yang Yang,

Diana Arseni,

Wenjuan Zhang,

Melissa Huang,

Sofia Lövestam,

Manuel Schweighauser,

Abhay Kotecha,

Alexey G. Murzin,

SewYeu PeakChew,

Jennifer A. Macdonald,

Isabelle Lavenir,

Holly J. Garringer,

Ellen Gelpí,

Kathy L. Newell,

Gábor G. Kovács,

Rubén Vidal,

Bernardino Ghetti,

Benjamin Falcon,

Sjors H. W. Scheres,

Michel Goedert

Publication year - 2022

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abm7285

Subject(s) - protein filament , intermediate filament , electron microscope , amyloid (mycology) , neurofilament , biophysics , human brain , alzheimer's disease , fibril , chemistry , biology , neuroscience , disease , cytoskeleton , pathology , medicine , biochemistry , immunohistochemistry , cell , physics , immunology , inorganic chemistry , optics

Hi-res view of human Aβ42 filaments Alzheimer’s disease is characterized by a loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain. The assembly of Aβ peptides into filaments that end at residue 42 is a central event. Yanget al . used electron cryo–electron microscopy to determine the structures of Aβ42 filaments from human brain (see the Perspective by Willem and Fändrich). They identified two types of related S-shaped filaments, each consisting of two identical protofilaments. These structures will inform the development of better in vitro and animal models, inhibitors of Aβ42 assembly, and imaging agents with increased specificity and sensitivity. —SMH

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research