mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern | Zendy

Rishi R. Goel | Zendy; Mark M. Painter | Zendy; Sokratis A. Apostolidis | Zendy; Divij Mathew | Zendy; Wenzhao Meng | Zendy; Aaron M. Rosenfeld | Zendy; Kendall A. Lundgreen | Zendy; Arnold Reynaldi | Zendy; David S. Khoury | Zendy; Ajinkya Pattekar | Zendy; Sigrid Gouma | Zendy; Leticia Kuri-Cervantes | Zendy; Philip Hicks | Zendy; Sarah Dysinger | Zendy; Amanda Hicks | Zendy; Harsh Sharma | Zendy; Sarah Herring | Zendy; Scott W. Korte | Zendy; Amy E. Baxter | Zendy; Derek A. Oldridge | Zendy; Josephine R. Giles | Zendy; Madison E. Weirick | Zendy; Christopher M. McAllister | Zendy; Moses Awofolaju | Zendy; Nicole Tanenbaum | Zendy; Elizabeth M. Drapeau | Zendy; Jeanette Dougherty | Zendy; Sherea Long | Zendy; Kurt D’Andrea | Zendy; Jacob T. Hamilton | Zendy; M. A. McLaughlin | Zendy; Justine C. Williams | Zendy; Sharon Adamski | Zendy; Oliva Kuthuru | Zendy; Ian Frank | Zendy; Michael R. Betts | Zendy; Laura A. Vella | Zendy; Alba Grifoni | Zendy; Daniela Weiskopf | Zendy; Alessandro Sette | Zendy; Scott E. Hensley | Zendy; Miles P. Davenport | Zendy; Paul Bates | Zendy; Eline T. Luning Prak | Zendy; Allison R. Greenplate | Zendy; E. John Wherry | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Author(s) -

Rishi R. Goel,

Mark M. Painter,

Sokratis A. Apostolidis,

Divij Mathew,

Wenzhao Meng,

Aaron M. Rosenfeld,

Kendall A. Lundgreen,

Arnold Reynaldi,

David S. Khoury,

Ajinkya Pattekar,

Sigrid Gouma,

Leticia Kuri-Cervantes,

Philip Hicks,

Sarah Dysinger,

Amanda Hicks,

Harsh Sharma,

Sarah Herring,

Scott W. Korte,

Amy E. Baxter,

Derek A. Oldridge,

Josephine R. Giles,

Madison E. Weirick,

Christopher M. McAllister,

Moses Awofolaju,

Nicole Tanenbaum,

Elizabeth M. Drapeau,

Jeanette Dougherty,

Sherea Long,

Kurt D’Andrea,

Jacob T. Hamilton,

M. A. McLaughlin,

Justine C. Williams,

Sharon Adamski,

Oliva Kuthuru,

Ian Frank,

Michael R. Betts,

Laura A. Vella,

Alba Grifoni,

Daniela Weiskopf,

Alessandro Sette,

Scott E. Hensley,

Miles P. Davenport,

Paul Bates,

Eline T. Luning Prak,

Allison R. Greenplate,

E. John Wherry

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abm0829

Subject(s) - immune system , immunology , vaccination , antibody , biology , virology , immunological memory , virus , longevity , covid-19 , disease , immunity , medicine , infectious disease (medical specialty) , genetics , pathology

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing severe COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding the longevity of vaccine-induced immune protection. Goelet al . examined B and T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study of individuals who never had SARS-CoV-2 infection compared with people who had recovered from SARS-CoV-2. Humoral and cellular immune memory was observed in vaccinated individuals, as were functional immune responses against the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) viral variants. Analysis of T cell activity suggested that robust cellular immune memory may prevent hospitalization by limiting the development of severe disease. —PNK

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research