A biomimetic S H 2 cross-coupling mechanism for quaternary sp 3 -carbon formation | Zendy

Wei Liu | Zendy; Marissa N. Lavagnino | Zendy; Colin A. Gould | Zendy; Jesús Alcázar | Zendy; David W. C. MacMillan | Zendy

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A biomimetic S _H 2 cross-coupling mechanism for quaternary sp ³ -carbon formation

Author(s) -

Wei Liu,

Marissa N. Lavagnino,

Colin A. Gould,

Jesús Alcázar,

David W. C. MacMillan

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abl4322

Subject(s) - homolysis , quaternary , chemistry , mechanism (biology) , carbon fibers , coupling (piping) , quaternary carbon , substitution (logic) , stereochemistry , radical , materials science , physics , organic chemistry , paleontology , geology , catalysis , enantioselective synthesis , quantum mechanics , composite number , computer science , metallurgy , composite material , programming language

Radical substitution Nucleophilic substitution is a venerable reaction in organic chemistry. Typically, an incoming ion delivers two electrons to a carbon center while a departing ion takes two electrons away with it. The one-electron analog, homolytic substitution, is more rarely used, in part because the incoming neutral radicals can self-couple instead of bonding to the intended target. Liuet al . report that an iron porphyrin catalyst can direct homolytic substitution between primary and tertiary carbon radicals by selectively activating the primary partners. —JSY

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