Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants | Zendy

Yongfei Cai | Zendy; Jun Zhang | Zendy; Tianshu Xiao | Zendy; Christy L. Lavine | Zendy; Shaun Rawson | Zendy; Hanqin Peng | Zendy; Haisun Zhu | Zendy; Krishna Anand | Zendy; Pei Tong | Zendy; Avneesh Gautam | Zendy; Shen Lu | Zendy; Sarah M. Sterling | Zendy; Richard M. Walsh | Zendy; Sophia RitsVolloch | Zendy; Jianming Lü | Zendy; Duane R. Wesemann | Zendy; Wei Yang | Zendy; Michael S. Seaman | Zendy; Bing Chen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Author(s) -

Yongfei Cai,

Jun Zhang,

Tianshu Xiao,

Christy L. Lavine,

Shaun Rawson,

Hanqin Peng,

Haisun Zhu,

Krishna Anand,

Pei Tong,

Avneesh Gautam,

Shen Lu,

Sarah M. Sterling,

Richard M. Walsh,

Sophia RitsVolloch,

Jianming Lü,

Duane R. Wesemann,

Wei Yang,

Michael S. Seaman,

Bing Chen

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abi9745

Subject(s) - infectivity , biology , virology , antibody , virus , immune system , spike (software development) , evasion (ethics) , coronavirus , immunity , spike protein , covid-19 , mutation , genetics , gene , disease , medicine , infectious disease (medical specialty) , management , pathology , economics

SARS-CoV-2 from alpha to epsilon As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern because they are resistant to antibodies elicited by infection or vaccination or they increase transmissibility or disease severity. Three papers used functional and structural studies to explore how mutations in the viral spike protein affect its ability to infect host cells and to evade host immunity. Gobeilet al . looked at a variant spike protein involved in transmission between minks and humans, as well as the B1.1.7 (alpha), B.1.351 (beta), and P1 (gamma) spike variants; Caiet al . focused on the alpha and beta variants; and McCallumet al . discuss the properties of the spike protein from the B1.1.427/B.1.429 (epsilon) variant. Together, these papers show a balance among mutations that enhance stability, those that increase binding to the human receptor ACE2, and those that confer resistance to neutralizing antibodies. —VV

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research