Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction | Zendy

Yue Li | Zendy; Linda D. Simmler | Zendy; Ruud van Zessen | Zendy; Jérôme Flakowski | Zendy; Jinxia Wan | Zendy; Fei Deng | Zendy; Yulong Li | Zendy; Katherine M. Nautiyal | Zendy; Vincent Pascoli | Zendy; Christian Lüscher | Zendy

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Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction

Author(s) -

Yue Li,

Linda D. Simmler,

Ruud van Zessen,

Jérôme Flakowski,

Jinxia Wan,

Fei Deng,

Yulong Li,

Katherine M. Nautiyal,

Vincent Pascoli,

Christian Lüscher

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abi9086

Subject(s) - dopamine , reuptake , addiction , serotonin , neuroscience , optogenetics , striatum , stimulation , pharmacology , reuptake inhibitor , chemistry , receptor , psychology , medicine , biology

Prevention of compulsive cocaine taking Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulnerability to drug addiction. However, the relevant circuits and underlying cellular processes remain elusive. Liet al . discovered a synaptic mechanism in mice that underlies the modulatory role of 5-HT in reducing the likelihood of transition to compulsion and eventually addiction (see the Perspective by Miyazaki and Miyazaki). Cocaine binds to 5-HT transporters to block 5-HT reuptake. The elevated extracellular 5-HT activates 5-HT1B receptors and causes presynaptic depression of a projection from the orbitofrontal cortex to the dorsal striatum. These changes reduce the likelihood of inducing postsynaptic potentiation at these synapses, which ultimately drives compulsion. —PRS

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