Fumarate is a terminal electron acceptor in the mammalian electron transport chain | Zendy

Jessica B. Spinelli | Zendy; Paul C. Rosen | Zendy; HansGeorg Sprenger | Zendy; Anna M. Puszynska | Zendy; Jessica L. Mann | Zendy; Julian M. Roessler | Zendy; Andrew L. Cangelosi | Zendy; Antonia Henne | Zendy; Kendall J. Condon | Zendy; Tong Zhang | Zendy; Tenzin Kunchok | Zendy; Caroline A. Lewis | Zendy; Navdeep S. Chandel | Zendy; David M. Sabatini | Zendy

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Fumarate is a terminal electron acceptor in the mammalian electron transport chain

Author(s) -

Jessica B. Spinelli,

Paul C. Rosen,

HansGeorg Sprenger,

Anna M. Puszynska,

Jessica L. Mann,

Julian M. Roessler,

Andrew L. Cangelosi,

Antonia Henne,

Kendall J. Condon,

Tong Zhang,

Tenzin Kunchok,

Caroline A. Lewis,

Navdeep S. Chandel,

David M. Sabatini

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abi7495

Subject(s) - electron transport chain , electron acceptor , electron flow , chemistry , biophysics , mitochondrion , cellular respiration , respiration , electron , chain (unit) , microbiology and biotechnology , biochemistry , biology , physics , photosynthesis , astronomy , botany , quantum mechanics

Reversing the chain The mitochondrial electron transport chain is a major part of cellular metabolism and plays key roles in both cellular respiration and the synthesis of critical metabolites. Typically, electrons flow through the electron transport chain in a specific direction, ending up with oxygen as the terminal electron acceptor. Spinelliet al . characterized an alternative path of electron flow through the transport chain, ending with fumarate as the electron acceptor (see the Perspective by Baksh and Finley). This pathway operates under conditions of limited oxygen availability, and the authors have confirmed its activity in vivo in a mouse model, observing that the propensity to use this pathway varied between organs. —YN

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