Open AccessBioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury
Author(s) -
Zaida Álvarez,
Alexandra N. Edelbrock,
Ivan R. Sasselli,
Juan A. Ortega,
Ruomeng Qiu,
Zois Syrgiannis,
Peter A. Mirau,
F. Chen,
Stacey M. Chin,
Steven Weigand,
Evangelos Kiskinis,
Samuel I. Stupp
Publication year - 2021
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abh3602
Subject(s) - microbiology and biotechnology , transmembrane protein , regeneration (biology) , chemistry , spinal cord injury , spinal cord , integrin , peptide , biophysics , receptor , scaffold , neuroscience , biology , biochemistry , medicine , biomedical engineering
Fibril motion improves peptide signaling Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarezet al . synthesized supramolecular peptide fibril scaffolds bearing two peptide sequences that promote nerve regeneration, one that reduces glial scarring and another that promotes blood vessel formation (see the Perspective by Wojciechowski and Stevens). In a mouse model of paralyzing human spinal cord injury, mutations in a tetrapeptide domain outside of the signaling regions improved recovery by promoting intense supramolecular motion within the fibrils. The mutation with the most intense dynamics resulted in corticospinal axon regrowth and myelination, functional revascularization, and motor neuron survival. —PDS
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom